Clinical indicator analysis for myocardial injury induced by type 2 diabetes mellitus

This study aimed to investigate the clinical indicators of myocardial injury induced by type 2 diabetes mellitus (T2DM). The study includes 23 patients with T2DM, also having myocardial injury, identified as the illness group (IG), and 46 T2DM patients, randomly assigned to the control group (CG). The IG was subdivided into the dysfunctional myocardial contraction group (DCG, n = 10; left ventricular ejection fraction [LVEF] < 50%) and the normal myocardial contraction group (NCG, n = 13; LVEF ≥ 50%). The disease course was independently associated with systolic dysfunction and defined as an LVEF < 50% (odds ratio [OR], 1.339; 95% confidence interval [CI], 1.032-1.737; P = 0.028). The triglyceride level was found to be an independent factor significantly associated with myocardial injury caused by T2DM (OR, 1.012; 95% CI, 1.002-1.022; P = 0.018). The thickness of the interventricular septum (IVS) was higher and the left ventricular fractional shortening was lower in patients of the DCG. The LVEF value was significantly correlated with the IVS thickness (r = -0.391, P = 0.001) and disease course (r = -0.261, P = 0.030). The disease course was a significant indicator of systolic dysfunction, indicating that along with the development of T2DM, myocardial injury exacerbates and finally leads to dysfunctional myocardial contraction. Every patient with T2DM has diastolic dysfunction to some degree, and systolic dysfunction and ventricular remodeling exist in patients with myocardial injury caused by T2DM. Elevated triglyceride levels in T2DM patients might promote the occurrence of diabetic myocardial injury.